HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Piperidine-2(S)-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperidine-2(R)-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenyl}-amide | HCID 135974922 | — |
| Reactant | 2(S)-{4-[3-(5-Chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester | HCID 135974931 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Piperidine-2(S)-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenyl}-amide | HCID 135974994 | — |
Reaction Steps
Using the same procedure for the preparation of 5A, treatment compound 9A with TFA in methylene chloride to give compound 10A in quantitative yield. Its 1H NMR and LCMS data are identical with those of compound 5A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07923004B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-b4c0e11e62ab4c9fbb678989d342cfa7 |
| Source note | uspto-grants-2011_04 |