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HRID2075767

反应详情

EQUATION

反应方程式

HRID 2075767 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)OC(=O)N[C@@H](C(=O)O)c1ccccc1
HCID2755953

Boc-D-Phg-OH

C13H17NO4

结构：O=C(Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1)[C@@H]1COCCN1
HCID135974932

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCOCC1C(=O)Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1)c1ccccc1
HCID135975022

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCOC[C@H]1C(=O)Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1)c1ccccc1
HCID135974930

未命名化合物

PROCEDURE

实验过程

Using the same procedure for the preparation of 18A, reaction of compound 21A with BOC-D-Phg-OH (11A) afforded the title compound 22A as a white powder in similar yield. 1H NMR (CDCl3, 500 MHz) δ 10.60 (s, 1H), 8.71 (s, 1H), 8.62 (s, 1H), 7.90 (d, 2H, J=8.5 Hz), 7.78 (s, 1H), 7.56 (d, 2H, J=8.5 Hz), 7.43 (m, 5H), 7.20 (dd, 1H, J=8.5, 1.5 Hz), 6.97 (d, 1H, J=9.0 Hz), 5.48 (d, 1H, J=6.5 Hz), 5.40 (d, 1H, J=6.0 Hz), 5.29 (s, 1H), 4.81 (d, 1H, J=12.0 Hz), 4.31 (t, 2H, J=5.0 Hz), 4.06 (m, 2H), 3.78 (d, 1H, J=10.5 Hz), 3.64 (t, 1H, J=12.5 Hz), 3.59 (t, 1H, J=1.0 Hz), 3.43 (dd, 1H, J=11.0, 2.5 Hz), 3.06 (t, 1H, J=10.5 Hz), 1.93 (t, 1H, J=5.0 Hz), 1.45 (s, 9H). LCMS (ESI) m/z 722.16 (MNa+), 700.18 (MH+), 644.13 (100), 600.11, 354.11. HPLC: tR=4.48 min.