HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Morpholine-3-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-methyl-1H-pyrazol-4-ylethynyl]-phenyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperidine-2(R)-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenyl}-amide | HCID 135974922 | — |
| Reactant | 3-{4-[3-(5-Chloro-2-hydroxy-phenyl)-1-methyl-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester | HCID 136346687 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Morpholine-3-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-methyl-1H-pyrazol-4-ylethynyl]-phenyl}-amide | HCID 136346686 | — |
Reaction Steps
Using the same procedure for the preparation of compound 5A, treatment of compound 6D with TFA in methylene chloride gives the title compound 7D as a white powder in similar yield. LCMS (ESI) m/z 437.28 (MH+, 100); HPLC: tR=4.15 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07923004B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-d9383c3f2d3543cf877bb93ef1fb1874 |
| Source note | uspto-grants-2011_04 |