Ammonium Hydroxide → 1H-Indole-2-carboxamide

Participants

Reaction Steps

Add to the 2-indole carboxylic acid (31.0 mmol) dissolved in anhydrous THF (50 ml), carbonyldiimidazole (1.10 equiv, 5.5 g, 34.0 mmol) and stir 1 h. Then add concentrated NH4OH (50 mL) in one portion and stir the reaction at rt. After 16 hours collect the solid that separates by filtration, wash with H2O and dry under vacuum at 40° C. to afford the desired 2-indole carboxamide.

Provenance & Evidence