反应详情

Add to 1.5 g of 3-(4-cyano-2-nitrophenyl)-2-oxopropionic acid ethyl ester, in EtOH (40 mL) 10% Pd/C (0.45 g) and stir under a hydrogen atmosphere until the theoretical amount of hydrogen is absorbed. Filter the mixture and concentrate the filtrate to afford 1.1 g of crude product. Purify by chromatography on SiO2 and elute with CH2Cl2. Concentrate the desired fractions and vacuum dry the residue over night (40° C.) to afford the title compound (0.8 g) as white crystals, mp 176° C.

1. customis absorbed
2. filtrationFilter the mixture
3. concentrationconcentrate the filtrate
4. customto afford 1.1 g of crude product
5. customPurify by chromatography on SiO2
6. washelute with CH2Cl2
7. concentrationConcentrate the desired fractions and vacuum
8. customdry the residue over night (40° C.)