Water → 4-benzyloxy-N-hydroxy-2-iodo-5-methoxy-benzimidoylchloride

Participants

Reaction Steps

To a mixture of 4-benzyloxy-2-iodo-5-methoxy-benzaldehyde oxime (reference example 2-1) (12.8 g) and N,N-dimethylformamide (110 mL) was added N-chlorosuccinimide (4.9 g) at room temperature. After stirring at room temperature for 20 minutes, water and ethyl acetate were added to the mixture under ice-bath cooling. The separated organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 4-benzyloxy-N-hydroxy-2-iodo-5-methoxy-benzimidoylchloride.

Provenance & Evidence