Dimethylformamide → Isopropyl 5-benzyloxy-4-methoxy-2-(5-methyl-[1,2,4]oxa-diazol-3-yl)benzoate

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-benzyloxy-4-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)benzoic acid (reference example 5-1) (308 mg), 2-iodopropane (0.225 mL), potassium carbonate (312 mg) and N,N-dimethylformamide (2.6 mL) was stirred at 60° C. for 2.5 hours. After cooling to room temperature, water and ethyl acetate were added to the mixture. The separated organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (342 mg).

Provenance & Evidence