反应详情

A mixture of acetic acid [5-benzyloxy-4-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-tert-butylcarbamoyl methyl ester (Reference example 12-1) (604 mg), a 5 mol/L aqueous solution of sodium hydroxide (1 mL) and methanol (8 mL) was stirred at room temperature for 1.5 hours. Ethyl acetate and water were added to the mixture. The separated organic layer was washed with water, an aqueous solution of sodium bicarbonate successively, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (552 mg).

1. washThe separated organic layer was washed with water
2. dry with materialan aqueous solution of sodium bicarbonate successively, dried over anhydrous magnesium sulfate
3. concentrationconcentrated under reduced pressure