反应详情

A mixture of [5-benzyloxy-4-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl]phenyl)phenylmethanol (reference example 6-1) (526 mg), manganese dioxide (1.18 g) and methylene chloride (6.8 mL) was stirred at room temperature overnight. After addition of manganese dioxide (1.18 g), the mixture was stirred for 7.5 hours, and manganese dioxide (0.59 g) was added, and the mixture was stirred overnight. The mixture was passed through a layer of Celite (registered mark). The filtrate was concentrated under reduced pressure to give the title compound (526 mg).

1. stirringthe mixture was stirred for 7.5 hours
2. stirringthe mixture was stirred overnight
3. concentrationThe filtrate was concentrated under reduced pressure