Dimethyl Sulfoxide → HCID 59565751, compound

Participants

Reaction Steps

To a mixture of 1-[5-benzyloxy-4-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]ethanol (reference example 6-2) (467 mg), triethylamine (0.956 mL) and dimethyl sulfoxide (6 mL) was added a mixture of pyridine sulfur trioxide complex (655 mg) and dimethyl sulfoxide (2 mL). After stirring at room temperature for 2 hours, water and ethyl acetate were added to the mixture. The separated organic layer was washed with 2 mol/L hydrochloric acid and brine successively, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 25%-34% ethyl acetate/hexane, gradient elution) to give the title compound (365 mg).

Provenance & Evidence