Hydrochloric Acid → HCID 136202030, compound

Participants

Reaction Steps

To a mixture of 3-(4-benzyloxy-2-methanesulfonyl-5-methoxyphenyl)-5-methyl-[1,2,4]oxadiazole and methylene chloride (20 mL) was added titanium(IV) chloride (0.472 g). After stirring at room temperature for 15 minutes, 2 mol/L hydrochloric acid and methylene chloride were added to the mixture. The separated organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 10%-100% ethylacetate/hexane, gradient elution) to give the title compound (112 mg).

Provenance & Evidence