HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2075965Generated: October 31, 2026
MAGNESIUM SILICATE (synthetic) → 3-(4-Benzyloxy-5-methoxy-2-triisopropylsilanylsulfanyl-phenyl)-5-methyl-[1,2,4]oxadiazole
https://huagongshe.com/reaction/2075965
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | MAGNESIUM SILICATE (synthetic) | HCID 61680 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | Tris(propan-2-yl)silanethiol | HCID 3435097 | — |
| Reactant | Bis[2-(diphenylphosphino)phenyl] ether | HCID 4285986 | — |
| Reactant | 3-(4-Benzyloxy-2-iodo-5-methoxyphenyl)-5-methyl-[1,2,4]oxa-diazole | HCID 50898861 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(4-Benzyloxy-5-methoxy-2-triisopropylsilanylsulfanyl-phenyl)-5-methyl-[1,2,4]oxadiazole | HCID 67096445 | — |
Reaction Steps
A mixture of 3-(4-benzyloxy-2-iodo-5-methoxyphenyl)-5-methyl-[1,2,4]oxadiazole (reference example 4-1) (0.7 g), triisopropylsilanethiol (0.391 mL), tris(dibenzylidene-acetone)dipalladium (0) (152 mg), (oxydi-2,1-phenylene)bis-(diphenylphosphine) (90 mg), sodium bis(trimethylsilyl)amide (1.0 mol/L tetrahydrofuran solution, 0.39 mL) and toluene (20 mL) was stirred at 80° C. for 2 hours under an argon atmosphere. After cooling to room temperature, Florisil (registered mark) (1 g) was added to the mixture. After stirring for 10 minutes, the mixture was passed through a layer of Celite (registered mark). The filtrate was concentrated under reduced pressure to give 3-(4-benzyloxy-5-methoxy-2-triisopropylsilanylsulfanyl-phenyl)-5-methyl-[1,2,4]oxadiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07923462B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-851bffeee6d046768f46b363f4c50a82 |
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| Source note | uspto-grants-2011_04 |
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