Bromine → 2-Bromo-6-(2-methoxy-phenyl)-cyclohexanone

HRID 2075986Notes

Reaction equation

HRID 2075986 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[C:10]1=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 282984Cyclohexanone,2-(2-methoxyphenyl)-

Product 1

HCID 670958932-Bromo-6-(2-methoxy-phenyl)-cyclohexanoneYield 64.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(2-Methoxy-phenyl)-cyclohexanone (51 mg, 0.27 mmol) was dissolved in chloroform (1 mL). To this solution bromine (45.4 mg, 0.28 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 3 hours at room temperature and the solvent was removed under reduced pressure to yield the crude title compound (49 mg) which was used directly in the next step without further purification.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-dfb7577146224dbeacf490966ca91a7a
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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