反应详情

温度

50 °C

2-(3-Methoxy-phenyl)-2-propyl-cyclohexanone (100 mg, 0.41 mmol) was dissolved in chloroform (1 mL). To this solution bromine (68.1 mg, 0.43 mmol) in chloroform (0.5 mL) was added drop wise at −11° C. The reaction was stirred at 5° C. for 1½ hours, at room temperature for 1 hour and at 50° C. for 1 hour. The solvent was removed under reduced pressure to yield the crude title compound (126 mg) which was used directly in the next step without further purification.

1. customThe solvent was removed under reduced pressure