Bromine → HCID 67095889, compound

HRID 2075990Notes

Reaction equation

HRID 2075990 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]2=[O:14])=[CH:4][C:3]=1[C:15]([F:18])([F:17])[F:16].[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:10]1[C:9](=[O:14])[CH:8]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([C:15]([F:16])([F:17])[F:18])[CH:4]=2)[CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 24408BromineHCID 21082587HCID 21082587, compound

Product 1

HCID 67095889HCID 67095889, compoundYield 104.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(4-Methyl-3-trifluoromethyl-phenyl)-cyclohexanone (50 mg, 0.20 mmol) was dissolved in chloroform (1 mL). To this solution bromine (32.7 mg, 0.21 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the title compound (70 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-c22f38f1dc7f4f4dbb07280d0728eca1
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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