Bromine → 6-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanone

HRID 2075992Notes

Reaction equation

HRID 2075992 reaction equation
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]2=[O:16])=[CH:6][CH:5]=1.[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:12]1[C:11](=[O:16])[CH:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:17])([F:18])[F:1])=[CH:9][CH:8]=2)[CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 24408BromineHCID 210825892-(4-Trifluoromethoxyl-phenyl)-cyclohexanone

Product 1

HCID 670961346-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanoneYield 91.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(4-Trifluoromethoxyl-phenyl)-cyclohexanone (53 mg, 0.21 mmol) was dissolved in chloroform (1 mL). To this solution bromine (34.4 mg, 0.22 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (65 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-9d1370a153124d72bfb1f0b3e567ff88
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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