Bromine → HCID 67095892, compound

HRID 2075996Notes

Reaction equation

HRID 2075996 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH:11]1[C:10](=[O:15])[CH:9]([C:3]2[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=2[F:1])[CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 24408BromineHCID 62801584HCID 62801584, compound

Product 1

HCID 67095892HCID 67095892, compoundYield 105.2%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(2,5-Difluoro-phenyl)-cyclohexanone (51 mg, 0.24 mmol) was dissolved in chloroform (1 mL). To this solution bromine (40.7 mg, 0.26 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the cude title compound (73 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-fe6c50fda1f34f438b9cfd0754564e67
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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