Bromine → 6-Bromo-2-(2-chloro-phenyl)-cyclohexanone

HRID 2076000Notes

Reaction equation

HRID 2076000 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=[O:14].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][CH:10]1[C:9](=[O:14])[CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 24408BromineHCID 43741102-(2-Chlorophenyl)cyclohexan-1-one

Product 1

HCID 670959316-Bromo-2-(2-chloro-phenyl)-cyclohexanoneYield 112.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(2-Chloro-phenyl)-cyclohexanone (51 mg, 0.25 mmol) was dissolved in chloroform (1 mL). To this solution bromine (42.3 mg, 0.27 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (81 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-3692381de02345ea9f4071bb1c056bd5
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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