Bromine → HCID 67095881, compound

HRID 2076002Notes

Reaction equation

HRID 2076002 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])[CH:5]=[CH:6][C:7]=1[CH3:8].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH:11]1[C:10](=[O:15])[CH:9]([C:4]2[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([F:1])[CH:3]=2)[CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 24408BromineHCID 21082579HCID 21082579, compound

Product 1

HCID 67095881HCID 67095881, compoundYield 103.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2 (3 fluoro-4-methyl-phenyl)-cyclohexanone (51 mg, 0.25 mmol) was dissolved in chloroform (1 mL). To this solution bromine (41.5 mg, 0.27 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the title compound (74 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-36eb9cba3e1348789c5398da955b0342
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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