Bromine → HCID 67096234, compound

HRID 2076003Notes

Reaction equation

HRID 2076003 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]2=[O:14])=[CH:4][C:3]=1[C:15]([F:18])([F:17])[F:16].[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:10]1[C:9](=[O:14])[CH:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:15]([F:16])([F:17])[F:18])[CH:4]=2)[CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 24408BromineHCID 21082584HCID 21082584, compound

Product 1

HCID 67096234HCID 67096234, compoundYield 82.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(4-Chloro-3-trifluoromethyl-phenyl)-cyclohexanone (50 mg, 0.18 mmol) was dissolved in chloroform (1 mL). To this solution bromine (30.3 mg, 0.19 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (53 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-d4db277334b4491aa475ff5a7a01d383
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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