Bromine → HCID 67096178, compound

Participants

Reaction Conditions

Reaction Steps

Benzyl-3-(4-chloro-3-fluorophenyl)-piperidin-4-one (100 mg, 0.33 mmol) was dissolved in chloroform (1 mL). To this solution bromine (53 mg, 0.33 mmol) in chloroform (0.5 mL) was added drop wise at −11° C. The reaction was stirred for 1½ hours at 5° C., for 1 hour at room temperature and for 1 hours at 50° C. The solvent was removed under reduced pressure to yield the crude title compound (147 mg) which was used directly in the next step without further purification.

Provenance & Evidence