Bromine → 2-Bromo-6-(2,4-dichloro-phenyl)-cyclohexanone

HRID 2076020Notes

Reaction equation

HRID 2076020 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[C:10]1=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 184417612-(2,4-Dichlorophenyl)cyclohexan-1-one

Product 1

HCID 670961512-Bromo-6-(2,4-dichloro-phenyl)-cyclohexanoneYield 116.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(2,4-Dichloro-phenyl)-cyclohexanone (50 mg, 0.21 mmol) was dissolved in chloroform (1 mL). To this solution bromine (34.5 mg, 0.22 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (79 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-e58ec677299a415091bce371896f7ad0
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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