Bromine → HCID 67096052, compound

HRID 2076023Notes

Reaction equation

HRID 2076023 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=2)[C:10]1=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 18441765HCID 18441765, compound

Product 1

HCID 67096052HCID 67096052, compoundYield 110.9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

2-(3,5-Dichloro-phenyl)-cyclohexanone (50 mg, 0.21 mmol) was dissolved in chloroform (1 mL). To this solution bromine (34.5 mg, 0.22 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (75 mg) which was used directly in the next step without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-3a96c65760a34358b34e4f5506d15c86
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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