HCID 67096230, compound → HCID 44193752, compound

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A suspension of [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (68 mg, 0.26 mmol) and of crude 2-bromo-6-(3,5-difluoro-phenyl)-cyclohexanone (78 mg, 0.27 mmol) in ethanol (2 mL) was heated to reflux under an atmosphere of nitrogen for 2 days. After cooling to room temperature the solvent was evaporated under reduced pressure and the residue was purified by reversed preparative HPLC using acetonitril/water (0.1% formic acid) to yield the title compound (40 mg, 34%) as a yellow solid. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.70 (s, 1H), 7.41 (s, 1H), 7.10 (d, 1H), 6.85 (s, 1H), 6.67-6.73 (m, 4H), 4.03 (m, 1H), 3.62 (s, 3H), 2.75 (m, 2H), 2.31 (s, 3H), 2.22 (m, 1H), 1.84 (m, 3H).

Provenance & Evidence