6-Bromo-2-methyl-2-phenyl-cyclohexanone → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(4-methyl-4-phenyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-amine

HRID 2076028Notes

Reaction equation

HRID 2076028 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:16]([NH2:18])=[S:17])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Br[CH:20]1[C:25](=O)[C:24]([CH3:33])([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:23][CH2:22][CH2:21]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:16]2[S:17][C:22]3[CH2:21][CH2:20][CH2:25][C:24]([CH3:33])([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[C:23]=3[N:18]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1

Participants

3

Reactant 2

HCID 581100436-Bromo-2-methyl-2-phenyl-cyclohexanoneHCID 71650841[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]thiourea

Product 1

HCID 44193753[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(4-methyl-4-phenyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-amine

Procedure

The title compound was prepared from [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (0.45 g, 1.72 mmol) and 6-bromo-2-methyl-2-phenyl-cyclohexanone (0.69 g, 2.6 mmol) using in analogous manner the procedure described in example 1b). Obtained as an off-white solid (0.29 g, 39%). MS ISP (m/e): 431.4 [(M+H)+]. mp 123-126° C.

Sources & evidence

ORD record
ord-e6c66c266a60475ba1d34f3c296dbb35
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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