6-Bromo-2-methyl-2-phenyl-cyclohexanone → [3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-(4-methyl-4-phenyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-amine

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Reaction Steps

The title compound was prepared from [3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (90 mg, 0.36 mmol) and crude 6-bromo-2-methyl-2-phenyl-cyclohexanone (0.29 g, ca. 1.1 mmol) using in analogous manner the procedure described in example 1b). Obtained as a light-brown solid (65 mg, 43%). MS (ISP) 419.3 [(M+H)+]. mp 160-164° C.

Provenance & Evidence