tert-Butoxy bis(dimethylamino)methane → HCID 67096186, compound

HRID 2076036Notes

Reaction equation

HRID 2076036 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O[CH:19](N(C)C)[N:20]([CH3:22])[CH3:21])(C)(C)C>>[CH3:19][N:20]([CH3:22])/[CH:21]=[C:9]1\[C:8](=[O:13])[CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11][CH2:10]\1

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 955922-Phenylcyclohexanone

Product 1

HCID 67096186HCID 67096186, compoundYield 101.2%

Procedure

A mixture of 2-phenylcyclohexanone (871 mg, 5.0 mmol) and of tert.-butoxy-bis(dimethylamino)methane (90%, 1.5 mL, 7 mmol) was stirred at 110° C. for 75 min. The reaction was evaporated to dryness under reduced pressure to give the crude title compound (1.16 g, 100%) as a red oil which was used directly in the next step without further purification. MS ISP (m/e): 230.2 (100) [(M+H)+].

Workup

  1. customThe reaction was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-2f1a10e79a5a49ada38527a61d39c5d6
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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