tert-Butoxy bis(dimethylamino)methane → HCID 67095888, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-boc-3-phenyl-piperidin-4-one (100 mg, 0.35 mmol) and tert.-butoxy-bis(dimethylamino)methane (94 mg, 0.48 mmol) was stirred at 110° C. for 2 hours. The reaction was evaporated to dryness, treated twice with toluene and evaporated under reduced pressure to dryness to yield the title compound (215 mg, 188%) as a brown oil which was used directly in the next step without further purification. MS ISP (m/e): 331.4 (79) [(M+H)+], 275.1 (100) [(M-isubutene +H)+].

Provenance & Evidence