tert-Butoxy bis(dimethylamino)methane → 6-[1-Dimethylamino-methylidene]-2-(3-trifluoromethyl-phenyl)-cyclohexanone

HRID 2076047Notes

Reaction equation

HRID 2076047 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])[CH:6]=[CH:7][CH:8]=1.C(O[CH:23](N(C)C)[N:24]([CH3:26])[CH3:25])(C)(C)C>>[CH3:23][N:24]([CH3:26])[CH:25]=[C:11]1[C:10](=[O:15])[CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:16])([F:17])[F:1])[CH:4]=2)[CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 210825822-[3-(Trifluoromethyl)phenyl]cyclohexanone

Product 1

HCID 670962416-[1-Dimethylamino-methylidene]-2-(3-trifluoromethyl-phenyl)-cyclohexanone

Procedure

2-(3-Trifluoromethyl-phenyl)-cyclohexanone (106 mg, 0.44 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a), to give crude title compound (132 mg) as a red oil which was used directly in the next step. MS ISP (m/e): 298.0 [(M+H)+]

Sources & evidence

ORD record
ord-80fec4453bfa4131b170f7773d0777bf
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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