6-[1-Dimethylamino-methylidene]-2-(3-trifluoromethyl-phenyl)-cyclohexanone → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-[8-(3-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-quinazolin-2-yl]-amine

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Reaction Steps

The title compound was prepared from 6-[1-dimethylamino-methylidene]-2-(3-trifluoromethyl-phenyl)-cyclohexanone (132 g, 0.44 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (163 mg, 0.44 mmol) using in analogous manner the procedure described in example 45b). Obtained as an off-white solid (62 mg, 29%). MS ISP (m/e): 480.1 [(M+H)−]. mp 213-215° C.

Provenance & Evidence