6-[1-Dimethylamino-methylidene]-2-(2,4-dichloro-phenyl)-cyclohexanone → [8-(2,4-Dichloro-phenyl)-5,6,7,8-tetrahydro-quinazolin-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Participants

Reaction Steps

The title compound was prepared from 6-[1-dimethylamino-methylidene]-2-(2,4-dichloro-phenyl)-cyclohexanone (105 mg, 0.35 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (131 mg, 0.35 mmol) using in analogous manner the procedure described in example 45b). Obtained as an off-white solid (19 mg, 11%). MS ISP (m/e): 480.1 [(M+H)+]. mp 256-258° C.

Provenance & Evidence