6-[1-Dimethylamino-methylidene]-2-(4-chloro-phenyl)-cyclohexanone → [8-(4-Chloro-phenyl)-5,6,7,8-tetrahydro-quinazolin-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Participants

Reaction Steps

The title compound was prepared from 6-[1-dimethylamino-methylidene]-2-(4-chloro-phenyl)-cyclohexanone (134 mg, 0.50 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (186 mg, 0.50 mmol) using in analogous manner the procedure described in example 45b). Obtained as an off-white solid (69 mg, 31%). MS ISP (m/e): 446.1 [(M+H)+]. mp 210-212° C.

Provenance & Evidence