6-[1-Dimethylamino-methylidene]-2-(4-fluoro-phenyl)-cyclohexanone → [8-(4-Fluoro-phenyl)-5,6,7,8-tetrahydro-quinazolin-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Participants

Reaction Steps

The title compound was prepared from 6-[1-dimethylamino-methylidene]-2-(4-fluoro-phenyl)-cyclohexanone (143 mg, 0.53 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (195 mg, 0.53 mmol) using in analogous manner the procedure described in example 45b). Obtained as an off-white solid (71 mg, 31%). MS ISP (m/e): 430.5 [(M+H)+]. mp 191-193° C.

Provenance & Evidence