Ethyl 3-[1-dimethylamino-methylidene]-2-oxo-cyclohexanecarboxylate → Ethyl 2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-5,6,7,8-tetrahydro-quinazoline-8-carboxylate

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Reaction Steps

The title compound was prepared from ethyl 3-[1-dimethylamino-methylidene]-2-oxo-cyclohexanecarboxylate (49 mg, 0.22 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (55 mg, 0.15 mmol) using in analogous manner the procedure described in example 45b). Obtained as a pale-yellow solid (8 mg, 10%). MS ISP (m/e): 408.4 [(M+H)+]. mp 162-164° C.

Provenance & Evidence