HCID 67096176, compound → Methyl 6,6-ethylendioxy-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-5,6,7,8-tetrahydro-quinazoline-8-carboxylate

HRID 2076064Notes

Reaction equation

HRID 2076064 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[C:15](=O)[C:14](=[CH:17]N(C)C)[CH2:13][C:7]2([O:11][CH:10](C)[CH2:9][O:8]2)[CH2:6]1)=[O:4].[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([NH:43][C:44]([NH2:46])=[NH:45])[CH:34]=[CH:35][C:36]=1[N:37]1[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]1>>[CH2:10]1[CH2:9][O:8][C:7]2([CH2:6][CH:5]([C:3]([O:2][CH3:1])=[O:4])[C:15]3[N:46]=[C:44]([NH:43][C:33]4[CH:34]=[CH:35][C:36]([N:37]5[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]5)=[C:31]([O:30][CH3:29])[CH:32]=4)[N:45]=[CH:17][C:14]=3[CH2:13]2)[O:11]1

Participants

3

Reactant 2

HCID 67096176HCID 67096176, compoundHCID 178493228HCID 178493228, compound

Product 1

HCID 57780688Methyl 6,6-ethylendioxy-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-5,6,7,8-tetrahydro-quinazoline-8-carboxylate

Procedure

The title compound was prepared from methyl 9-[1-dimethylamino-methylidene]-8-oxo-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid methyl ester (80 mg, 0.3 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (83 mg, 0.22 mmol) using in analogous manner the procedure described in example 45b). Obtained as a pale-yellow solid (37 mg, 27%). MS ISP (m/e): 452.1 [(M+H)+]. mp 180-182° C.

Sources & evidence

ORD record
ord-adf7dae702174b85ba8b2fe1c6e883c1
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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