6-[1-Dimethylamino-methylidene]-2-(3-trifluoromethyl-phenyl)-cyclohexanone → [3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-[8-(3-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-quinazolin-2-yl]-amine

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The title compound was prepared from crude 6-[1-dimethylamino-methylidene]-2-(3-trifluoromethyl-phenyl)-cyclohexanone (172 mg, 0.5 mmol) and N-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (134 mg, 0.37 mmol) using in analogous manner the procedure described in example 45b). Obtained as a pale-yellow solid (106 mg, 61%). MS ISP (m/e): 468.3 [(M+H)+]. mp 207-209° C.

Provenance & Evidence