tert-Butoxy bis(dimethylamino)methane → HCID 86761298, compound

HRID 2076070Notes

Reaction equation

HRID 2076070 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]2=[O:19])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.C(O[CH:27](N(C)C)[N:28]([CH3:30])[CH3:29])(C)(C)C>>[F:1][C:2]([F:20])([F:21])[C:3]1[CH:4]=[C:5]([CH:13]2[CH2:18][CH2:17][CH2:16][C:15](=[CH:27][N:28]([CH3:30])[CH3:29])[C:14]2=[O:19])[CH:6]=[C:7]([C:9]([F:11])([F:12])[F:10])[CH:8]=1

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 58820538HCID 58820538, compound

Product 1

HCID 86761298HCID 86761298, compound

Procedure

2-(3,5-Bis-trifluoromethyl-phenyl)-cyclohexanone (155, 0.5 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a) to give crude title compound (184 mg) as a red oil which was used directly in the next step. MS ISP (m/e): 366.1 [(M+H)+].

Sources & evidence

ORD record
ord-baff07850d314b0496343277d9812bdf
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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