tert-Butoxy bis(dimethylamino)methane → HCID 67095917, compound

HRID 2076087Notes

Reaction equation

HRID 2076087 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]2=[O:16])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].C(O[CH:22](N(C)C)[N:23]([CH3:25])[CH3:24])(C)(C)C>>[CH3:22][N:23]([CH3:25])/[CH:24]=[C:12]1\[C:11](=[O:16])[CH:10]([C:4]2[CH:3]=[C:2]([F:1])[C:7]([F:8])=[C:6]([F:9])[CH:5]=2)[CH2:15][CH2:14][CH2:13]\1

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 200967681172639-14-3

Product 1

HCID 67095917HCID 67095917, compound

Procedure

2-(3,4,5-Trifluoro-phenyl)-cyclohexanone (100 mg, 0.44 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a) to give crude title compound (123 mg) as a brown oil which was used directly in the next step. MS ISP (m/e): 284.2 (100) [(M+H)+].

Sources & evidence

ORD record
ord-d16f773df9744b569da4cba999e234ec
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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