HCID 67096318, compound → HCID 57780711, compound

HRID 2076092Notes

Reaction equation

HRID 2076092 reaction equation
CN(C)/[CH:3]=[C:4]1/[C:5](=O)[CH:6]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:7][CH2:8][CH2:9]/1.[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([NH:40][C:41]([NH2:43])=[NH:42])[CH:31]=[CH:32][C:33]=1[N:34]1[CH:38]=[C:37]([CH3:39])[N:36]=[CH:35]1>>[CH:10]1([CH:6]2[C:5]3[N:43]=[C:41]([NH:40][C:30]4[CH:31]=[CH:32][C:33]([N:34]5[CH:38]=[C:37]([CH3:39])[N:36]=[CH:35]5)=[C:28]([O:27][CH3:26])[CH:29]=4)[N:42]=[CH:3][C:4]=3[CH2:9][CH2:8][CH2:7]2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 67096318HCID 67096318, compoundHCID 178493228HCID 178493228, compound

Product 1

HCID 57780711HCID 57780711, compound

Procedure

The title compound was prepared from crude 3-[1-dimethylamino-meth-(E)-ylidene]-bicyclohexyl-2-one (84 mg, 0.36 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (111 mg, 0.30 mmol) using in analogous manner the procedure described in example 45b). Obtained as yellow crystals (61 mg, 49%). MS ISP (m/e): 418.3 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=9.57 (s, 1H), 8.21 (s, 1H), 7.90 (s, 1H), 7.65 (s, 1H), 7.39 (d, 1H), 7.21 (d, 1H), 7.03 (s, 1H), 3.82 (s, 3H), 2.51-2.65 (m, 2H), 2.14 (s, 3H), 1.72-1.94 (m, 3H), 1.52-1.70 (m, 5H), 1.02-1.35 (m, 7H).

Sources & evidence

ORD record
ord-fd8f444d5b1045f8a76a229c06837223
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

Loading…