反应详情

The title compound was prepared from crude 2-(tert-butyl-dimethyl-silanyloxy)-6-[1-dimethylamino-meth-(E)-ylidene]-cyclohexanone (80 mg, 0.28 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (74 mg, 0.20 mmol) using in analogous manner the procedure described in example 45b). Obtained as an orange gum (27 mg, 29%). MS ISP (m/e): 466.3 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=9.49 (s, 1H), 8.32 (s, 1H), 7.72 (d, 1H), 7.65 (s, 1H), 7.54 (s, 1H), 7.18 (d, 1H), 7.02 (s, 1H), 4.60 (m, 1H), 3.78 (s, 3H), 2.60-2.70 (m, 1H), 2.14 (s, 3H), 1.86 (m, 3H), 1.72 (m, 1H), 0.85 (s, 9H), 0.20 (s, 3H), 0.05 (s, 3H).