tert-Butoxy bis(dimethylamino)methane → HCID 67096114, compound

HRID 2076098Notes

Reaction equation

HRID 2076098 reaction equation
[OH:1][C:2]1([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8].C(O[CH:20](N(C)C)[N:21]([CH3:23])[CH3:22])(C)(C)C>>[CH3:20][N:21]([CH3:23])/[CH:22]=[C:4]1\[CH2:5][CH2:6][CH2:7][C:2]([OH:1])([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[C:3]\1=[O:8]

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 448908492-Hydroxy-2-(pyridin-3-yl)cyclohexan-1-one

Product 1

HCID 67096114HCID 67096114, compound

Procedure

2-Hydroxy-2-pyridin-3yl-cyclohexanone (394 mg, 2 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a) to give crude title compound (582 mg) as a brown oil which was used directly in the next step. MS ISP (m/e): 247.2 (100) [(M+H)+].

Sources & evidence

ORD record
ord-af9f0c7445964dd0b6ca72bc6b48a81b
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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