Ammonium Hydroxide → HCID 86632609, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-(4-phenyl-4,5,6,7-tetrahydro-benzothiazol-2-ylamino)-benzoic acid (810 mg, 2.1 mmol) and 1,1′-carbonyldiimidazol (463 mg, 2.8 mmol) in dimethylformamide (15 mL) was stirred for 30 minutes at 50° C. The solution was cooled to 0° C. and 25% aqueous ammonium hydroxide solution (1.6 mL, 21.3 mmol) was added slowly. The reaction mixture was stirred for 45 minutes at room temperature. The reaction was poured onto water, stirred for 15 minutes and the solid was filtered off, washed with water and dried to yield the title compound (661 mg, 82%) as an off-white solid. mp 243-246° C. MS ISP (m/e): 380.4 (100) [(M+H)+].

Provenance & Evidence