Methylamine → HCID 11281862, compound

Participants

Reaction Steps

A solution of compound 90-1 (100 mg, 0.21 mmol) and 0.3 ml of methylamine 90-J (R′═CH3, R′═H) in THF (2N) in DMSO (2 ml) was heated to 60° C. for 1 hour. The reaction mixture was purified by HPLC (Dionex System) using 10-50% CH3CN/H2O+0.1% AcOH over 30 minutes to give N-cyclopropyl-2-methyl-6-({7-[2-(methylamino)ethoxy]quinolin-4-yl}oxy)-1-benzofuran-3-carboxamide 90 (42 mg).

Provenance & Evidence