Sodium Hydroxide → HCID 178456844, compound

HRID 2076261Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[C:12](S(C)(=O)=O)[N:11]=[C:10]([C:18]2[S:22][C:21]([NH:23][CH:24]([CH3:26])[CH3:25])=[N:20][CH:19]=2)[CH:9]=1.[OH-:27].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[C:10]([C:18]2[S:22][C:21]([NH:23][CH:24]([CH3:26])[CH3:25])=[N:20][CH:19]=2)[N:11]=[C:12]([OH:27])[N:13]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86607004HCID 86607004, compound

Product 1

HCID 178456844HCID 178456844, compound

Procedure

Example 318 was prepared from 5-(6-(2-chlorophenyl)-2-(methylsulfonyl)pyrimidin-4-yl)-N-isopropylthiazol-2-amine utilizing a similar procedure as described in Example 50 by substituting 1-methylpiperazine with 1N NaOH aqueous solution. Yellow solid. HPLC Ret. time: 2.55 min. LCMS MH+ (m/z) 347.20. 1H NMR: (d6-DMSO, 500 MHz) δ 11.58 (br, 1H), 8.41 (d, 1H), 8.12 (s, 1H), 7.60 (m, 1H), 7.55 (m, 2H), 7.48 (m, 1H), 6.86 (br. s, 1H), 3.86 (m, 1H), 1.18 (d, 6H).

Sources & evidence

ORD record: ord-4293fba6ae7946ab9a54a54fe5dab403
Source dataset: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07923556B2

Reaction notes

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