Dimethylformamide → Methyl 3-methoxy-4-nitrobenzoate

Participants

Reaction Steps

Methyl iodide (463 g) was added dropwise to a DMF (1 L) mixture of 3-hydroxy-4-nitrobenzoic acid (199 g) and potassium carbonate (450 g) at room temperature. The reaction liquid was stirred overnight at room temperature, to which methyl iodide (230 g) was further added, followed by additionally stirring the reaction liquid at room temperature for 6 hours. The reaction liquid was added to ice water, followed by collecting the precipitated solid by filtration. The resultant solid was dried overnight at 50° C. to provide 178 g of the title compound. The physical property values thereof agreed with reported values (CAS#5081-37-8).

Provenance & Evidence