Water → Methyl 4-amino-3-methoxybenzoate

Participants

Reaction Steps

To a solution of methyl 3-methoxy-4-nitrobenzoate (150 g) in methanol (600 mL) and THF (300 mL) was added 10% palladium-carbon (a 50% water-containing product, 15 g), and the reaction liquid was stirred at 50° C. to 64° C. under a hydrogen pressure of 0.9 MPa for 6.5 hours. The reaction liquid was allowed to stand to cool to room temperature and then filtered on celite, followed by concentrating the resultant filtrate under reduced pressure to provide 134 g of the title compound. The physical property values thereof agreed with reported values (CAS#41608-64-4).

Provenance & Evidence