Formic Acid → Methyl 4-formamido-3-methoxybenzoate

Participants

Reaction Steps

Acetic anhydride (268 mL) was added dropwise to formic acid (401 mL) at room temperature, and the reaction liquid was stirred at room temperature for 40 minutes. A THF (600 mL) solution of methyl 4-amino-3-methoxybenzoate (134 g) was added dropwise to the reaction liquid at room temperature, and the resultant reaction liquid was stirred for one hour. To the reaction liquid was added 3.8 L of ice water, and the precipitated solid was collected by filtration and further washed with water (2 L). The resultant solid was dried overnight at 50° C. to provide 111 g of the title compound. The physical property values thereof agreed with reported values (CAS#700834-18-0).

Provenance & Evidence