(R)-(-)-1-Aminoindan → [5-(4-Fluoro-benzyloxy)-quinolin-2-yl]-(R)-indan-1-yl-amine

Participants

Reaction Steps

2-Chloro-5-(4-fluoro-benzyloxy)-quinoline (100 mg, 0.347 mmol) and (R)-1-aminoindane (138 mg, 1.04 mmol) were stirred in a sealed tube at 150° C. overnight. The reaction mixture was purified by flash chromatography on silica gel (heptane/ethyl acetate 75:25). The title compound was obtained as a light brown oil (68 mg, 51%), MS: m/e=385 (M+H+).

Provenance & Evidence