(R)-(-)-1-Aminoindan → HCID 67096056, compound

HRID 2076280Notes

Reaction equation

HRID 2076280 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=1)[CH2:18]Br.[NH2:23][C@H:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25]1>>[C@H:24]1([NH:23][C:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[O:1][CH2:18][C:17]3[CH:20]=[CH:21][CH:22]=[C:15]([O:14][CH3:13])[CH:16]=3)[N:7]=2)[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 2733933(R)-(-)-1-AminoindanHCID 40672073-Methoxybenzyl bromideHCID 1354422212-chloroquinolin-5-ol

Product 1

HCID 67096056HCID 67096056, compound

Procedure

The title compound, MS: m/e=397.5 (M+H+), was prepared in accordance with the general method of example 2 from 5-hydroxy-2-chloroquinoline, 3-methoxy-benzylbromide and (R)-1-aminoindane.

Sources & evidence

ORD record
ord-fb78cf6245ae4569a9f4e49adf366dca
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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