3-(Bromomethyl)pyridine → HCID 25018801, compound

HRID 2076281Notes

Reaction equation

HRID 2076281 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.Br[CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1.[NH2:21][C@H:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1>>[C@H:22]1([NH:21][C:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[O:1][CH2:14][C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)[N:7]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1

Participants

4

Reactant 3

HCID 2459343-(Bromomethyl)pyridineHCID 2733933(R)-(-)-1-AminoindanHCID 1354422212-chloroquinolin-5-ol

Product 1

HCID 25018801HCID 25018801, compound

Procedure

The title compound, MS: m/e=367.5 (M+H+), was prepared in accordance with the general method of example 2 from 5-hydroxy-2-chloroquinoline, 3-bromomethyl-pyridine and (R)-1-aminoindane.

Sources & evidence

ORD record
ord-da360fca2b774a21b8537db0d89b1760
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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